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Aging_Longevity

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South Africa, Aging and Longevity NAD Level = 81 and Normal is 100+
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Ampath Labs

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Dr_Abram_Hoffer

  • Posted on 05/03/2010 12:36 pm
This new work with NAD Therapy is very exciting and I think is right on target. It is indeed an energy-metabolic-deficiency (EMD) because in the absence of this coenzyme cycle almost all the reactions in the body run down... I congratulate Theo Verwey and his colleagues for this remarkable advance in using this concept and in using a simple test, the ratio of pyruvate to lactate as a diagnostic measure, to indicate the dose, duration of treatment etc.

NAD_Blood_Tests

  • Posted on 05/01/2010 12:02 pm
The ratio of lactate to pyruvate reflects the NAD/NADH ratio and is useful in distinguishing primary defects. Measured enzymatically in blood or CSF as an index of defects of glucose oxidation (fed state) or gluconeogenesis (fasted). (Center Inherited Disorders Energy Metabolism at CWR University School of Medicine, Cleveland, Ohio).

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My NAD Articles Doccumenting NAD Relevancy

Ten years of NAD-dependent SIR2 family deacetylase…

Since the discovery of NAD-dependent deacetylase activity of the silent information regulator-2 (SIR2) family ('sirtuins'), many exciting connections between protein deacetylation and energy metabolis… Read more

Synaptic utilization of lactate/pyruvate and neura…

Neuronal cells usually utilize glucose as a principal metabolic fuel and monocarboxylates including lactate and pyruvate are alternative energetic substrates in the central nervous system.

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Stimulus-induced brain lactate: effects of aging a…

Both aging and sleep deprivation disturb the functions of the frontal lobes. Deficits in brain energy metabolism have been reported in these conditions.

Neurons use not only glucose but … Read more

Nicotinamide adenine dinucleotide, a metabolic reg…

Nicotinamide adenine dinucleotide (NAD) is a ubiquitous biological molecule that participates in many metabolic reactions.

Recent studies show that NAD also plays important roles in tran… Read more

MR spectroscopy detection of lactate and lipid sig…

Magnetic resonance spectroscopy was used to assess the presence of brain lactate and lipid signals, frequently associated with the presence of pathology, in healthy persons of 60-90 years old (n = 540… Read more

Manipulation of a Nuclear NAD+ Salvage Pathway Del…

Yeast deprived of nutrients exhibit a marked life span extension that requires the activity of the NAD+-dependent histone deacetylase, Sir2p.

Here we show that increased dosage of NPT1, … Read more

Elevation of cerebrospinal fluid lactate with agin…

It has been hypothesized that cerebral oxidative glucose metabolism may become impaired with age and lead to deterioration of neuronal function. One marker of impaired cerebral oxidative glucose metab… Read more

Changes in NAD levels in human lymphocytes and fib…

NAD levels markedly increase upon mitogen stimulation of lymphocytes from young subjects. In contrast, lymphocytes from old subjects do not increase NAD levels upon stimulation.

A survey… Read more

Age-related changes in cerebral lactate metabolism…

Thirty-one patients, aged 22-71 years, with nocturnal apneic episodes and/or habitual snoring were studied with magnetic resonance spectroscopy (MRS) and diagnostic polysomnography separately to deter… Read more

Anti-Aging Medicine: Molecular Basis for Endotheli…

Due to improvements in lifestyle and healthcare, the proportion of aged people is rising steadily, especially in developed countries.

With aging, some physiological functions are altered… Read more

Biochemical markers of aging.

It is the purpose of this report to identify possible metabolic deficiencies that might serve as biochemical markers of aging. It is proposed that the multiplicity of physical and physiological change… Read more



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