Biochemical and enzymatic aspects of tryptophan-niacin metabolism were studied in 15 adult alcoholic pellagra patients and in 14 controls.
In addition to the clinical signs of niacin def… Read more
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Alcoholism
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My NAD Articles Doccumenting NAD Relevancy
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Tryptophan metabolism in alcoholic pellagra patien…
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The biochemistry of alcohol metabolism
The metabolism of ethanol to acetaldehyde in the liver proceeds via alcohol dehydrogenase (ADH) and the microsomal ethanol-oxidizing system (MOS), whereas catalase plays no significant role.
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Relationship between acetaldehyde levels and cell …
We have created a number of recombinant Hep G2 cell lines, designated VA cells, that constitutively express alcohol dehydrogenase.
Oxidation of ethanol by the VA cells results in the pro… Read more |
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Mitochondrial dysfunction of human muscle in chron…
We previously examined the effect of alcohol on muscle energy metabolism in chronic alcoholics by using 31P-magnetic resonance spectroscopy.
Measurements of intracellular pH and PCr inde… Read more |
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Metabolic effects of alcohol.
The metabolic effects of ethanol are due to a direct action of ethanol or its metabolites, changes in the redox state occurring during its metabolism, and modifications of the effects of ethanol by nu… Read more
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Ketoacidosis and lactic acidosis--frequent causes …
In clinical medicine, severe keto- or lactic acidosis associated with vomiting, nausea, abdominal pain, tachycardia or pathological respiration, has been described in chronic alcoholics.
… Read more |
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Does ethanol explain the acidosis commonly seen in…
OBJECTIVE: Emergency physicians frequently treat ethanol-intoxicated trauma patients. In patients with apparently minor injuries, the presence of metabolic acidosis is often attributed to serum ethano… Read more
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Alcoholic fatty liver: its pathogenesis and mechan…
Liver disease in the alcoholic is due not only to malnutrition but also to ethanol's hepatotoxicity linked to its metabolism by means of the alcohol dehydrogenase and cytochrome P450 2E1 (CYP2E1) path… Read more
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Biochemical mechanisms of alcohol-induced hepatic …
Three decades of research in ethanol metabolism have established that alcohol is hepatotoxic not only because of secondary malnutrition but also through metabolic disturbances associated with the oxid… Read more
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Research on alcohol metabolism: a historical persp…
The primary enzymatic steps in ethanol metabolism to acetaldehyde, acetate and CO2 + water have been known for many decades, but only a few clinical implications were recognized, such as the risk of m… Read more
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Alcohol exposure may induce fatty liver by increas…
Alcoholic fatty liver is a potentially pathologic condition which can progress to steatohepatitis, fibrosis, and cirrhosis if alcohol consumption is continued.
Alcohol exposure may induc… Read more |
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Alcohol induced changes of carbohydrate metabolism
It is evident that ethanol by itself or one of its metabolites produces alterations in transport, metabolism and disposition of carbohydrates.
Ethanol acts via changes in the redox state … Read more |
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