This article summarizes data from experimental and clinical oncology which are indicative of a pivotal role of tumor carbohydrate metabolism in malignant behavior and outcome of treatment.
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Cancer
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My NAD Articles Doccumenting NAD Relevancy
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Lactate and redox status in malignant tumors
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An association of carcinogenesis and decrease of c…
It is postulated that a decrease in nicotinamide adenine dinucleotide (NAD) concentration has a primary association with carcinogenesis. The following observations are presented as evidence:
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Mapping the role of NAD metabolism in prevention a…
Studies presented here show that cellular NAD, which we hypothesize to be the relevant biomarker of niacin status, is significantly lower in humans than in the commonly studied animal models of carcin… Read more
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Correlation of high lactate levels in head and nec…
Using quantitative bioluminescence imaging, tissue concentrations of ATP, glucose, and lactate were registered in biopsies that were taken from primary tumors of human head and neck at the time of fir… Read more
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Enhanced poly ADP-ribosylation in human leukemia l…
Freshly isolated human peripheral blood lymphocytes from leukemia (AML, ALL, CML) subjects, showed a 2.5-3.5-fold increase in the poly ADPR transferase (poly ADPRT) activity whereas ovarian cancers sh… Read more
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Evaluating the role of niacin in human carcinogene…
Our understanding of the role of ADP-ribose polymer metabolism in limiting carcinogenic events and the dependence of this metabolism on cellular NAD levels predicts that niacin deficiency leading to r… Read more
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Severe lactic acidosis in a 14-year-old female wit…
A 14-year-old girl was found to have a large, non-tender breast mass with anemia and thrombocytopenia. The diagnosis of an undifferentiated carcinoma of unknown primary was made after open breast biop… Read more
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Metabolism of vitamins B1 and PP and their use in …
Blood of patients with gastric tumor was studied after their admission to the hospital and after the chemotherapeutic course. Formation of the tumor was accompanied by development of hypovitaminoses B… Read more
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Niacin deficiency and cancer in women.
A new interest in the relationship between niacin and cancer has evolved from the discovery that the principal form of this vitamin, NAD, is consumed as a substrate in ADP-ribose transfer reactions. P… Read more
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Niacin and carcinogenesis.
The dietary status of niacin (vitamin B3) has the potential to influence DNA repair, genomic stability, and the immune system, eventually having an impact on cancer risk, as well as the side effects o… Read more
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Biochemical assessment of niacin deficiency among …
OBJECTIVE: Carcinoid cancer patients often have elevated levels of serotonin or its precursor 5-hydroxytryptophan. Normally, serotonin synthesis accounts for a small fraction of tryptophan catabolism,… Read more
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Hexokinase and lactate dehydrogenase activity, lac…
Certain glycolytic enzymes, the level of end metabolites of glycolysis and acid-base equilibrium indices were studied in 106 patients with stomach tumors (stage II-III).
It was found tha… Read more |
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NAD and adenosine triphosphate (ATP) concentration…
It is postulated that a decrease in nicotinamide adenine dinucleotide (NAD) concentration has a primary association with carcinogenesis.
The following observations are presented as evide… Read more |
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