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Cardiac_Disorders

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South Africa, Cardiac Disorders NAD Relevancy See My Blogs
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Dr_Abram_Hoffer

  • Posted on 05/04/2010 09:03 am
This new work with NAD Therapy is very exciting and I think is right on target. It is indeed an energy-metabolic-deficiency (EMD) because in the absence of this coenzyme cycle almost all the reactions in the body run down... I congratulate Theo Verwey and his colleagues for this remarkable advance in using this concept and in using a simple test, the ratio of pyruvate to lactate as a diagnostic measure, to indicate the dose, duration of treatment etc.

NAD_Blood_Tests

  • Posted on 05/01/2010 12:26 pm
The ratio of lactate to pyruvate reflects the NAD/NADH ratio and is useful in distinguishing primary defects. Measured enzymatically in blood or CSF as an index of defects of glucose oxidation (fed state) or gluconeogenesis (fasted). (Center Inherited Disorders Energy Metabolism at CWR University School of Medicine, Cleveland, Ohio).

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My NAD Articles Doccumenting NAD Relevancy

Serial lactate determinations for prediction of ou…

We investigated the relationship between lactate clearance and outcome in patients surviving the first 48 hours after cardiac arrest.

We conducted the study in the emergency department o… Read more

Effective lactate clearance is associated with imp…

INTRODUCTION: Early, effective lactate clearance has been shown to be associated with improved mortality in patients with trauma, burns, and sepsis. We investigated whether early, high lactate clearan… Read more

Skeletal muscle biochemistry and histology in ambu…

Recent studies in patients with long-term heart failure have suggested that intrinsic abnormalities in skeletal muscle can contribute to the development of early lactic acidosis and fatigue during exe… Read more

Increased myocardial NADPH oxidase activity in hum…

OBJECTIVES: This study was designed to investigate whether nicotinamide adenine dinucleotide 3-phosphate (reduced form) (NADPH) oxidase is expressed in the human heart and whether it contributes to re… Read more

Free fatty acid kinetics and oxidation in congesti…

To characterize fuel utilization of patients with congestive heart failure (CHF), we measured serum free fatty acid (FFA), counterregulatory hormone concentrations, whole body substrate oxidation rate… Read more

ED use of rapid lactate to evaluate patients with …

STUDY OBJECTIVE: To test the hypothesis that ED arrival venous lactate levels can be used to diagnose acute myocardial infarction (AMI) and to identify patients with critical illness in the triage of … Read more

NAD(+), sirtuins, and cardiovascular disease.

Cardiovascular disease (CVD) is the most prevalent disease worldwide and there is intense interest in pharmaceutical approaches to reduce the burden of this chronic, aging-related condition.
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Acid-base disturbances in heart failure

Disturbance in acid-base balance is commonly observed in patients with heart failure.

The most common disturbance is metabolic alkalosis combined with hypokalemia, as a result of the exc… Read more



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