 |
Diabetes
|
Movie Trailers Illustrating My NAD Deficiencies
My NAD Articles Doccumenting NAD Relevancy
 |
Changes in the redox state in the retina and brain…
Diabetic retinopathy is thought to result from chronic changes in the metabolic pathways of the retina. Hyperglycemia leads to increased intracellular glucose concentrations, alterations in glucose de… Read more
|
 |
Evaluation of a sorbitol dehydrogenase inhibitor o…
AIMS/HYPOTHESIS: Studies of the role of sorbitol dehydrogenase in nerve functional deficits induced by diabetes reported contradictory results. We evaluated whether sorbitol dehydrogenase inhibition r… Read more
|
 |
Elevated glucose levels increase retinal glycolysi…
PURPOSE. To assess effects of elevated glucose levels on retinal glycolysis and sorbitol pathway metabolism.
METHODS. Freshly isolated retinas from normal male Sprague-Dawley rats were i… Read more |
 |
Effect of nicotinamide on the uptake and release o…
Studies of neurotransmitter uptake and release by isolated rats brain cortex synaptosomes demonstrated that [2-14C]serotonin uptake was by 41% lower in streptozotocin-diabetic rats as compared to cont… Read more
|
 |
The use of nicotinamide in the prevention of type …
Nicotinamide can protect the NOD mouse from diabetes if given early enough and in sufficient dose. The effect partly wanes with time. There is reduced islet inflammation. Similar protective effects ca… Read more
|
 |
Hyperglycemic Pseudohypoxia and Diabetic Complicat…
In hypoxic tissues these vascular changes are linked to metabolic imbalances associated with impaired oxidation of NADH to NAD and the resulting increased ratio of NADH/NAD.
In hyperglyc… Read more |
 |
Nicotinamide and Prevention of Insulin-dependent D…
As a result of beta cell destruction, islet cell antibodies (ICA) can be demonstrated in the circulation. These antibodies can be detected up to eight years prior to overt IDDM.
Nicotina… Read more |
 |
Molecular Mechanisms of Beta-cell Destruction in I…
Autoimmune processes are involved in pancreatic beta-cell destruction in type 1 diabetes... Generation of free radicals, DNA strand breaks, activation of the enzyme poly (ADP-ribose) polymerase (PARP)… Read more
|
 |
Pyridine nucleotides in glucose metabolism and dia…
"Nicotinamide adenine dinucleotide (NAD) and its derivatives NADH, NADP and NADPH have regulatory functions in the generation of triose phosphates and pyruvate from glucose. In many studies of th… Read more
|
 |
Diabetic neuropathies. Metabolism of sorbitol in s…
The increase of sorbitol and fructose levels caused by aldose reductase activation and sorbitol dehydrogenase inhibition were observed in sciatic nerve of streptozotocin-diabetic rats. Elevated polyol… Read more
|
 |
Cerebrospinal fluid lactate in patients with diabe…
Cerebrospinal fluid (CSF) lactate and pyruvate concentrations were determined in 20 patients with diabetes mellitus but without disturbance of consciousness and five who recovered from hypoglycaemic c… Read more
|
 |
The burden of diabetic foot ulcers.
Lower extremity ulcers represent a major concern for patients with diabetes and for those who treat them, from both a quality of life and an economic standpoint. Studies to evaluate quality of life ha… Read more
|
 |
The elevation of blood lactate is associated with …
Increased blood lactate concentration and alterations of substrate utilization have been shown to be partly involved in development of insulin resistance in obese and type 2 diabetic patients.
… Read more |
Comments
Add comment
Dr_Abram_Hoffer
NAD_Blood_Tests