Traumatic_Brain_Injuries
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Persistent metabolic crisis as measured by elevate…
OBJECTIVE: To determine whether persistent metabolic dysfunction in normal-appearing frontal lobe tissue is correlated with long-term tissue atrophy. DESIGN: Prospective monitoring with retrospective … Read more
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Venous glucose and arterial lactate as biochemical…
BACKGROUND: Early assessment of injury severity is important in trauma. Trauma scores are calculated after the fact and are useful for audit and research, but not in the emergency clinical setting. Gl… Read more
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Predictive value of serum lactate dehydrogenase in…
Serum total lactate dehydrogenase (LDH) was estimated serially for up to 15 days in 110 patients with head injuries who had no extraneural injury. Increase in LDH activity generally indicated the degr… Read more
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Assessment of the lower limit for cerebral perfusi…
BACKGROUND: In patients with severe traumatic brain lesions, the lower limit for cerebral perfusion pressure (CPP) is controversial. The aim of this prospective study was to assess this limit from bed… Read more
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Cerebral acid-base homeostasis after severe trauma…
OBJECT: Brain tissue acidosis is known to mediate neuronal death. Therefore the authors measured the main parameters of cerebral acid-base homeostasis, as well as their interrelations, shortly after s… Read more
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Changes in concentration of cerebrospinal fluid co…
Brain injury, like other central nervous system pathologies, causes changes in the composition of the cerebrospinal fluid (CSF). In this study, changes in the concentration of small molecules of the C… Read more
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Oxidative stress in the brain: novel cellular targ…
Despite our present knowledge of some of the cellular pathways that modulate central nervous system injury, complete therapeutic prevention or reversal of acute or chronic neuronal injury has not been… Read more
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