BACKGROUND: The mechanism linking obesity with its downstream complications is poorly understood. Accumulating evidence suggests that insufficient oxidative capacity plays a central role in the development of insulin resistance and, perhaps, hypertension.
METHODS: To investigate this hypothesis, we measured lactate, a marker of the gap between energy expenditure and oxidative capacit…
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Association of lactate with blood pressure before and after rapid weight loss.
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Acute tryptophan depletion and sweet food consumption by overweight adults.
Serotonergic involvement has been implicated in preferential consumption of treat foods. We tested the effect of acute tryptophan depletion (ATD) on food consumption by overweight and lean adults with and without a history of recurrent major depressive disorder (MDD).
ATD and taste-matched placebo challenges were administered double-blind in counter-balanced order. Participants were … |
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Nicotinamide nucleotides as factors of lipogenesis regulation
Data are analyzed on a regulatory effect of the redox state of NAD- and NADP-couples (the free NAD+-/NADH, NADP+/NADPH ratios) on certain enzymic links of lipogenesis.
A concept is formulated on coordination of the activity of lipogenesis key enzymes by a common signal, supposedly by changes in the NAD+/NADH and NADP+/NADPH values in cytoplasm and mitochondria of the rat liver cells.… |
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