Changes in NAD+ and its metabolites contribute to longevity and age-associated diseases.
The role of NAD+ metabolism in bone diseases has however not been investigated, despite the fact that osteoporosis is a leading cause of morbidity in old age. TRAP(+) osteoclast formation from C57 Bl/6J mice was assessed after the addition of varying concentrations of NAD+ metabolites or exogenou…
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Extracellular NAD+ metabolism modulates osteoclastogenesis.
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