To determine the effects of an 8-wk dietary iron supplementation (100 mg.d-1) on low plasma ferritin concentration (< 20 ng.ml-1) and endurance, 20 active women (19-35 yr) were studied while performing a VO2max test and an endurance test (80% VO2max) on a cycle ergometer.
Subjects were randomly placed in an iron supplement (IG) or a placebo group (PG) using a double-blind method. …
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Effects of iron repletion on VO2max, endurance, and blood lactate in women.
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Do cardiac output and serum lactate levels indicate blood transfusion requiremen…
BACKGROUND: Whether and when to transfuse in anemia of prematurity is highly controversial. Some authors suggest transfusions simply if the hemoglobin (Hb) level is below a defined normal range. Others propose the use of clinical or laboratory parameters in anemic patients to decide whether to transfuse or not.
HYPOTHESIS: A decreasing amount of circulating Hb should cause a compensa… |
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Lactic acidosis and oxygen debt in African children with severe anaemia.
A syndrome of severe anaemia (Hb < or = 5 g/dl), particularly severe malarial anaemia (SMA), remains a major cause of childhood mortality in sub-Saharan Africa.
We hypothesized that the lactic acidosis which identifies those at the greatest risk of death often represents an oxygen debt incurred as a result of inadequate tissue perfusion. To examine this hypothesis, we measured oxy… |
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A randomized trial to develop criteria for administering erythrocyte transfusion…
A randomized trial of erythrocyte transfusion vs no transfusion was performed in 16 preterm infants 1 to 3 months old with hematocrits of less than or equal to 0.29 L/L.
To determine which (if any) such patients definitely benefit from transfusion, an analysis of outcome variables was performed. Factors that prospectively identified patients who would benefit from transfusions includ… |
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A patient with severe iron-deficiency anemia and memory disturbance.
A 56-year-old woman presented with severe iron-deficiency anemia and memory disturbance. She had been in a state of severe iron deficiency for many years due to an unbalanced diet.
Aerobic exercise test revealed an abnormal elevation of lactate and pyruvate reflecting mitochondrial dysfunction. After iron replacement therapy, WAIS verbal IQ score improved from 63 to 83, and levels of… |
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High levels of lactate, pyruvate, and alanine in anemic children.
Lactate, pyruvate, and alanine levels were investigated in patients with iron deficiency anemia and other types of anemia.
The study was carried out on 36 children between 2 and 16 years of age. The study group was divided into three groups, each comprised of 12 children. It was shown that the anemic children have lower PO2, higher PCO2 and higher levels of lactate, pyruvate, and ala… |
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