Several risk factors for coronary artery disease (CAD) induce atherosclerosis through endothelial activation and dysfunction, and ample evidence now suggests that the balance between production and removal of reactive oxygen species (ROS) - a condition termed oxidative stress - is implicated in such processes.
A main source of ROS in vascular cells is the reduced nicotinamide adenine…
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Eschaemia during arterial reconstructive surgery. Biochemical changes as reflect…
Blood gases, electrolytes, metabolites and enzymes were studied in the venous effluate from the leg and in the systemic blood of 8 patients suffering from obliterating arteriosclerosis, during and after reconstructive arterial surgery. The common femoral artery was clamped for 50 to 180 min.
Marked hypoxia and acidosis, together with a rise in lactate, phosphate and creatinine concen… |
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Mechanisms of endothelial survival under shear stress.
Endothelial cells (ECs) are exposed to cytotoxic reactive oxygen species and oxidation products of NO, yet they are characterized by low apoptotic rates and have an average life span of many years.
EC exposure to flow has been shown to downregulate cell cycle-related genes and cause cytoskeletal rearrangement. We hypothesized that exposure to flow also causes molecular and physiologi… |
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Physical activity and peripheral atherosclerosis.
This article describes changes in the muscular blood flow and metabolism in intermittent claudication (pain in the legs during physical work) and the effect of physical training on these factors.
The disease (arteriosclerosis obliterans) is characterized by a reduction in the blood flow through muscles and in oxygen uptake, together with increased lactate excretion during work, usual… |
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Inflammation may be a bridge connecting hypertension and atherosclerosis.
Pathogenesis of the atherosclerotic process is deemed as multi-factorial, and characterized by chronic inflammatory response.
Although hypertension is known to be one of the most important risk factors for atherosclerosis in causasians, its relative contribution to early atherosclerosis are still unknown. Increased evidence has indicated that hypertension, through the vasoactive pept… |
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Diagnostic value of the cerebrospinal fluid-blood lactate quotient in mental dis…
The lactate levels of cerebrospinal fluid and blood were measured enzymatically and simultaneously in 40 gero-psychiatric patients. After calculating the fluid-blood-lactate-quotients, two distinct groups emerged, whose mean quotients showed significant difference.
In the first group (15 patients) with a mean quotient of 1.06, the diagnosis of cerebral arteriosclerosis was clinically… |
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Content of nicotinamide coenzymes, metabolites and the NAD-dependent dehydrogena…
Study of the key mechanisms, metabolism regulators, showed that in the blood of patients with atherosclerosis the NAD/NAD . N ratio decreases by 59.8% and the NAD+ concentration by 44%, while the NAD . N content increases by 56.7%.
In the nicotinamide adenine dinucleotide system there is a general tendency tomards accumulation:the concentration of NADP+ grows by 218.6% and that of NA… |
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