OBJECTIVE: To investigate the current state of knowledge regarding the neurobiology of suicide and suicidality.
METHOD: The literature on the neurobiology of suicidality and suicide was reviewed.
RESULTS: There is clear evidence that the activity of 3 neurobiological systems has a role in the pathophysiology of suicidal behaviour. This includes hyperactivity of the hypo…
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The neurobiology of suicide and suicidality.
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Molecular genetics in the analysis of suicide.
Each year, one million people die of suicide. Among the different identified risk factors, genetic factors seem to be part of a multidimensional behavior, including psychiatric, psychosocial, biological factors and physical illness.
Family studies have provided evidence for familial transmission in suicide, confirmed in twin and adoption studies. At a molecular level, serotonin seems… |
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The genetics of suicidal behavior
There is consistent evidence suggesting that genetic factors play an important role in predisposition to suicidal behavior. Family, twin, and adoption studies have demonstrated that there is a genetic dimension to suicide.
Although there is some overlap between suicide and mood disorders, even among psychiatric groups with the highest risk, some patients never attempt suicide, indica… |
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