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Asthma

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Asthma

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Metabolic acidosis in status asthmaticus.

Blood gases and acid-base balance were measured in a group of patients in status asthmaticus. Simple or combined metabolic acidosis was found in 37.9% of the patients. In 25 of these, lactic acid (LA), pyruvic acid (PA) and LA/PA were increased.

Increased glycolysis and anaerobic respiratory muscle glycolysis during extreme airways obstruction may be instrumental in these changes. Base deficit, not accounted for by organic acid increase, may be dependent on previously present hypocapnic hyperventilation. Possibly hyperlactemia provoked by hyperventilation may be exaggerated in severe asthma.

About the Authors

Roncoroni AJ, Adrougue HJ, De Obrutsky CW, Marchisio ML, Herrera MR. (1976) Metabolic acidosis in status asthmaticus. Respiration. 1976;33(2):85-94.

Comments

Dr_Abram_Hoffer

  • Posted on 05/14/2010 01:43 am
This new work with NAD Therapy is very exciting and I think is right on target. It is indeed an energy-metabolic-deficiency (EMD) because in the absence of this coenzyme cycle almost all the reactions in the body run down... I congratulate Theo Verwey and his colleagues for this remarkable advance in using this concept and in using a simple test, the ratio of pyruvate to lactate as a diagnostic measure, to indicate the dose, duration of treatment etc.

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