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Cytochemical activity of mitochondrial enzymes in Parkinson's disease

Using cytochemical computerized morphometric method, activity of the key enzymes of energetic metabolism (succinate dehydrogenase, alpha-glycerophosphate dehydrogenase, malate dehydrogenase, glutamate dehydrogenase and lactate dehydrogenase) was studied in blood lymphocytes of 75 patients with Parkinson's disease and 15 healthy controls.

The signs of systemic mitochondrial insufficiency, which correlated with the disease duration and severity, were found in all the patients, including those with juvenile parkinsonism.

These data may provide a basis for introducing cytochemical monitoring as well as for administration of modern "mitochondrial" drugs (yantavit, coenzyme Q10, L-carnitine, etc).

About the Authors

Polevaia EV, Ivanova-Smolenskaia IA, Illarioshkin SN, Sukhorukov VS, Markova ED. (2004) Cytochemical activity of mitochondrial enzymes in Parkinson's disease. Zh Nevrol Psikhiatr Im S S Korsakova. 2004;104(5):42-5.

Comments

Dr_Abram_Hoffer

  • Posted on 06/06/2010 11:16 am
This new work with NAD Therapy is very exciting and I think is right on target. It is indeed an energy-metabolic-deficiency (EMD) because in the absence of this coenzyme cycle almost all the reactions in the body run down... I congratulate Theo Verwey and his colleagues for this remarkable advance in using this concept and in using a simple test, the ratio of pyruvate to lactate as a diagnostic measure, to indicate the dose, duration of treatment etc.

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