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Patients with borderline personality disorder may have lower brain serotonin synthesis

The method for measuring serotonin synthesis in human brain uses [11C]alpha-methyl-L-tryptophan as a tracer and positron emission tomography. The alpha-methyl-L-tryptophan is converted to alpha-methylserotonin, which is not a substrate for monoamine oxidase and therefore accumulates in the brain.

In a pilot study published recently, rates of serotonin synthesis were found to be higher in men than in women. This was due to the lower plasma free tryptophan in the women under the experimental conditions used, and does not necessarily reflect the situation in all circumstances.

Acute tryptophan depletion lowered brain serotonin synthesis by 90% or more.

Patients with borderline personality disorder, who exhibit emotional lability and impulsivity, may have lower brain serotonin synthesis rates than healthy controls.

About the Authors

Young SN, Leyton M, Benkelfat C. (1999) Pet studies of serotonin synthesis in the human brain. Adv Exp Med Biol. 1999;467:11-8. Department of Psychiatry, McGill University, Montreal, Quebec, Canada.

Comments

NAD_Blood_Tests

  • Posted on 05/09/2010 08:25 am
It is known that dietary tryptophan can be converted to nicotinamide nucleotides in the body. Both the level of tryptophan and the energy content of the diet have been shown to influence the efficiency of conversion. The rate at which tryptophan is converted to nicotinamide nucleotides in the body may be expected to be influenced by the activities of the enzymes concerned with the tryptophan-NAD pathway.

NAD_Blood_Tests

  • Posted on 04/28/2010 04:31 pm
The ratio of lactate to pyruvate reflects the NAD/NADH ratio and is useful in distinguishing primary defects. Measured enzymatically in blood or CSF as an index of defects of glucose oxidation (fed state) or gluconeogenesis (fasted). (Center Inherited Disorders Energy Metabolism at CWR University School of Medicine, Cleveland, Ohio).

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