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NAD was significantly decreased in patients with cervix and breast carcinoma

The levels of nicotinamide adenine dinucleotide (NAD) and NADH in blood of patients with cancer in various stages of development as well as their modification after glucose administration were determined in 188 respectively 77 cases.

NAD was significantly decreased in patients with cervix and breast carcinoma but unaltered in patients with metastatic cancers (and lung carcinoma) comparatively with healthy subjects. At 48 hours after i.v. administration of glucose, NAD increased significantly in patients with cervix carcinoma but was unaltered in patients with metastatic cancers (an lung carcinoma).

NADH in both cases has given little conclusive results.

About the Authors

Comes R, Mustea I. (1976) The levels of NAD and NADH in blood of patients with cancer. Neoplasma. 1976;23(4):451-5.

Comments

NAD_Blood_Tests

  • Posted on 04/28/2010 04:32 pm
The ratio of lactate to pyruvate reflects the NAD/NADH ratio and is useful in distinguishing primary defects. Measured enzymatically in blood or CSF as an index of defects of glucose oxidation (fed state) or gluconeogenesis (fasted). (Center Inherited Disorders Energy Metabolism at CWR University School of Medicine, Cleveland, Ohio).

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