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Hexokinase and lactate dehydrogenase activity, lactic and pyruvic acid content of erythrocytes and acid-base equilibrium in stom

Posted on 05/07/2010
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Certain glycolytic enzymes, the level of end metabolites of glycolysis and acid-base equilibrium indices were studied in 106 patients with stomach tumors (stage II-III).

It was found that prior to surgery metabolic disturbances in erythrocytes are to be observed, while acid-base indices tend toward metabolic acidosis.

After radical surgery, the activity levels of hexokinase and lactate, dehydrogenase as well as concentrations of lactic and pyruvic acids are decreased, acid-base equilibrium being restored much earlier.

About the Authors

Golub IKh, Kazantsev FN. (1981) Hexokinase and lactate dehydrogenase activity, lactic and pyruvic acid content of erythrocytes and acid-base equilibrium in stomach cancer patients after radical operations. Vopr Onkol. 1981;27(9):24-7.

Comments

Dr_Abram_Hoffer

Posted on 05/16/2010 01:41 pm

This new work with NAD Therapy is very exciting and I think is right on target. It is indeed an energy-metabolic-deficiency (EMD) because in the absence of this coenzyme cycle almost all the reactions in the body run down... I congratulate Theo Verwey and his colleagues for this remarkable advance in using this concept and in using a simple test, the ratio of pyruvate to lactate as a diagnostic measure, to indicate the dose, duration of treatment etc.