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An association of carcinogenesis and decrease of cellular NAD concentration.

Posted on 05/12/2010
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It is postulated that a decrease in nicotinamide adenine dinucleotide (NAD) concentration has a primary association with carcinogenesis. The following observations are presented as evidence:

(1) NAD and adenosine triphosphate (ATP) concentrations are lower in cancer cells;
(2) chemical carcinogens and radiation can cause a lowering of NAD concentration in precancerous cells: (3) biosynthesis of NAD in Ehrlich ascites tumor cells is altered; and
(4) NAD is involved in regulating deoxyribonucleic acid (DNA) synthesis.

The lowering of NAD concentration would lead to the expression of oncogene and/or virogene according to the protovirus hypothesis, and the cellular characteristics of cancer cells can also be explained through the lowering of cellular NAD concentration. Experimental approaches are also proposed.

About the Authors

Chung KT. (1982) An association of carcinogenesis and decrease of cellular NAD concentration. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1982 Nov;15(4):309-18.

Comments

Dr_Abram_Hoffer

Posted on 05/16/2010 06:51 pm

This new work with NAD Therapy is very exciting and I think is right on target. It is indeed an energy-metabolic-deficiency (EMD) because in the absence of this coenzyme cycle almost all the reactions in the body run down... I congratulate Theo Verwey and his colleagues for this remarkable advance in using this concept and in using a simple test, the ratio of pyruvate to lactate as a diagnostic measure, to indicate the dose, duration of treatment etc.