Earl Partridge (Jason Robards), a successful producer of television game shows, left his wife when she contracted cancer to marry the younger and more beautiful Linda (Julianne Moore). Now, Earl has cancer himself, and Linda spends her day fetching medicines and trying to deal with the imminent death of her husband, whom she has only now come to love. Earl asks his nurse Phil (Philip Seymour Hoffman) to arrange a meeting with his estranged son, Frank Mackey (Tom Cruise), known for his self-help program "Seduce and Destroy," in which he preaches the importance of male sexual prowess; he cared for his mother after Earl left her, and he has no desire to see his father again.