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Kevin Kline stars as George, a down-on-his-luck architect in this tearjerker from Irwin Winkler (At First Sight, Guilty By Suspicion). A disdainful local character who draws disapproval from the community, particularly his neighbor played by Mary Steenburgen, George sets out to change his life after suddenly losing his longtime job and discovering he's terminally ill (he has cancer). Attempting to reconnect with his estranged and troubled son, Sam (Hayden Christiansen), George endeavors to spend the summer they have together building his dream home by the sea.
This article summarizes data from experimental and clinical oncology which are indicative of a pivotal role of tumor carbohydrate metabolism in malignant behavior and outcome of treatment.
It is postulated that a decrease in nicotinamide adenine dinucleotide (NAD) concentration has a primary association with carcinogenesis. The following observations are presented as evidence: Read more
Studies presented here show that cellular NAD, which we hypothesize to be the relevant biomarker of niacin status, is significantly lower in humans than in the commonly studied animal models of carcin… Read more
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My NAD Articles Doccumenting NAD Relevancy
Lactate and redox status in malignant tumors
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An association of carcinogenesis and decrease of c…
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Mapping the role of NAD metabolism in prevention a…