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The effect of exposure duration on the blood level of glucose, pyruvate and lactate in acute carbon monoxide intoxication in man

Blood glucose, pyruvate and lactate were examined during hospitalization of 13 cases of acute carbon monoxide poisoning developing from short (less than or equal to 1.5 h) or long (10-14 h) exposure. CO intoxication resulted in increased blood levels of all carbohydrate metabolites studied.

Increased levels of pyruvate and lactate were much more pronounced and lasted for a longer time following long, compared with short, CO exposure despite similar blood COHb level (about 40% at the beginning of hospitalization). The results showed difference in biochemical effect of short and long single exposure to CO that could not be detected by the measurement of COHb.

About the Authors

Sokal JA. (1985) The effect of exposure duration on the blood level of glucose, pyruvate and lactate in acute carbon monoxide intoxication in man. J Appl Toxicol. 1985 Dec;5(6):395-7.

Comments

Dr_Abram_Hoffer

  • Posted on 05/16/2010 01:47 pm
This new work with NAD Therapy is very exciting and I think is right on target. It is indeed an energy-metabolic-deficiency (EMD) because in the absence of this coenzyme cycle almost all the reactions in the body run down... I congratulate Theo Verwey and his colleagues for this remarkable advance in using this concept and in using a simple test, the ratio of pyruvate to lactate as a diagnostic measure, to indicate the dose, duration of treatment etc.

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