We investigated the relationship between lactate clearance and outcome in patients surviving the first 48 hours after cardiac arrest.
We conducted the study in the emergency department of an urban tertiary care hospital. We analyzed the data for all 48-hour survivors after successful resuscitation from cardiac arrest during a 10-year period.
Serial lactate measurements,…
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Serial lactate determinations for prediction of outcome after cardiac arrest.
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Effective lactate clearance is associated with improved outcome in post-cardiac …
INTRODUCTION: Early, effective lactate clearance has been shown to be associated with improved mortality in patients with trauma, burns, and sepsis. We investigated whether early, high lactate clearance was associated with reduced mortality in post-cardiac arrest patients.
METHODS: We performed a retrospective analysis of post-cardiac arrest patients in an urban emergency department.… |
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Skeletal muscle biochemistry and histology in ambulatory patients with long-term…
Recent studies in patients with long-term heart failure have suggested that intrinsic abnormalities in skeletal muscle can contribute to the development of early lactic acidosis and fatigue during exercise. T
he present study provides an analysis of substrate and enzyme content, fiber typing, and capillarization in skeletal muscle biopsy samples obtained at rest from the vastus latera… |
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Increased myocardial NADPH oxidase activity in human heart failure.
OBJECTIVES: This study was designed to investigate whether nicotinamide adenine dinucleotide 3-phosphate (reduced form) (NADPH) oxidase is expressed in the human heart and whether it contributes to reactive oxygen species (ROS) production in heart failure.
BACKGROUND: A phagocyte-type NADPH oxidase complex is a major source of ROS in the vasculature and is implicated in the pathophys… |
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Free fatty acid kinetics and oxidation in congestive heart failure.
To characterize fuel utilization of patients with congestive heart failure (CHF), we measured serum free fatty acid (FFA), counterregulatory hormone concentrations, whole body substrate oxidation rates (indirect calorimetry), and the turnover and oxidation rates of FFA ([1-(14)C]-palmitate infusion) in 7 patients with CHF and in 7 cardiac patients without CHF after an overnight fast.
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ED use of rapid lactate to evaluate patients with acute chest pain.
STUDY OBJECTIVE: To test the hypothesis that ED arrival venous lactate levels can be used to diagnose acute myocardial infarction (AMI) and to identify patients with critical illness in the triage of ED patients presenting with chest pain.
METHODS: This was a prospective, double-blind, clinical study in an urban, academic ED. We enrolled a convenience sample of adult patients who had… |
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NAD(+), sirtuins, and cardiovascular disease.
Cardiovascular disease (CVD) is the most prevalent disease worldwide and there is intense interest in pharmaceutical approaches to reduce the burden of this chronic, aging-related condition.
The sirtuin (SIRT) family of NAD(+)-dependent protein deacetylases and ADP-ribosyltransferases have emerged as exciting targets for CVD management that can impact the cardiovascular system both d… |
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Acid-base disturbances in heart failure
Disturbance in acid-base balance is commonly observed in patients with heart failure.
The most common disturbance is metabolic alkalosis combined with hypokalemia, as a result of the excessive use of loop diuretics. Occasionary, hypoxia due to pulmonary edema stimulates ventilation, resulting in respiratory alkalosis. When pulmonary edema develops, carbon dioxide retention occurs, re… |
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