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Autofluorescence microscopy of fresh cervical-tissue sections reveals alteration…
Fluorescence spectroscopy offers an effective, noninvasive approach to the detection of precancers in multiple organ sites. Clinical studies have demonstrated that fluorescence spectroscopy can provide highly sensitive, specific and cost-effective diagnosis of cervical precancers. However, the underlying biochemical mechanisms responsible for differences in the fluorescence spectra of normal and d…
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The levels of NAD and NADH in blood of patients with cancer.
The levels of nicotinamide adenine dinucleotide (NAD) and NADH in blood of patients with cancer in various stages of development as well as their modification after glucose administration were determined in 188 respectively 77 cases.
NAD was significantly decreased in patients with cervix and breast carcinoma but unaltered in patients with metastatic cancers (and lung carcinoma) comp… |
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High lactate levels predict likelihood of metastases, tumor recurrence, and rest…
Pathophysiological parameters such as vascular density and tissue oxygen pressure can influence tumor malignancy and patient survival.
Observations from our group showed that metastatic spread of carcinomas of the uterine cervix and of head and neck cancers was closely correlated with the lactate concentration in the primary lesion. Because these results were obtained in a low number… |
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Having children with different men and subsequent cancer risk. A nationwide stud…
The more men by whom a woman has children, the more diverse will be the foetal antigens of paternal origin introduced into her bloodstream, and we investigated whether this has an impact on subsequent cancer risks.
By using population registries we identified 64704 women who had children with at least two different partners from 1973 to 1996 in Denmark. We compared their cancer incid… |
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Correlation of high lactate levels in human cervical cancer with incidence of me…
Tissue concentrations of ATP, glucose, and lactate in cervical cancer biopsies that were taken before a conventional radiation treatment were imaged quantitatively with a bioluminescence technique.
Concomitantly, a number of clinically relevant data, such as local tumor control, patient survival, metastatic spread, etc., were documented. There was no correlation between staging or gr… |
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