Despite this popular belief, it would seem that conditions similar to ME/CFS have been around for considerably longer than is generally assumed. For instance, as far back as 1750, Sir Richard Manningham reported a syndrome referred to as 'febricula' (or 'little fever') that had a large number of symptoms but was hard to objectively diagnose. In addition, there have been suggestions in recent well-regarded medical journals such as the Lancet and British Medical Journal, that historical figures such as Florence Nightingale, and Charles Darwin may have suffered from a similar illness.