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In order to evaluate whether the lactic acidosis is developed during incremental exercise test in COPD. 12 untrained subjects with COPD performed incremental maximal cycle ergometer tests. Ventilation (VE); O2 uptake (VO2), CO2 output (VCO2); and end-tidal CO2 fraction (FETCO2) were measured.

Arterial lactate concentration and blood gas analysis were measured at rest, maximal exercis…

Two patients with chronic obstructive pulmonary disease and chronic respiratory failure who developed acute lactic acidosis are described.

The initial arterial blood gas values in both patients had the pattern of acute respiratory failure with no metabolic disturbance. It was the calculation of the \"anion gap\" that provided the clue to the presence of metabolic acidosis, …

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