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The athlete, cocaine, and lactic acidosis: a hypothesis.
The muscular makeup of the sprint-trained athlete may make him especially susceptible to severe lactic acidosis from cocaine-induced seizures. Because of a high percentage of glycolytic muscle fibers (compared to the muscle fiber type of the endurance-trained athlete), the lactic acidosis and heat generated from muscular activity is much greater in the sprint-trained athlete than in the endurance-…
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Cocaine and exercise: alpha-1 receptor blockade does not alter muscle glycogenol…
In our previous work, we routinely observed that a combined cocaine-exercise challenge results in an abnormally rapid muscle glycogen depletion and excessive blood lactacidosis.
These phenomena occur simultaneously with a rapid rise in norepinephrine and in the absence of any rise in epinephrine. We postulated that norepinephrine may cause vasoconstriction of the muscle vasculature t… |
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Loss of weight and acute abdominal pain in a 38-year-old psychostimulant abuser
MATERIAL AND METHODS: A 38-year-old psychostimulant abuser was admitted to hospital after syncope. He had lost much of his weight over the last 6 months, had abdominal pain the last 10 days and bloody diarrhoea and hypotension upon admittance. The abdomen was soft and non-tender.
Due to renal failure and metabolic acidosis with base excess of -16 to -22 mmol/L and lactate from 9.5 to… |
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