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Depression

Depression

Depression

Depression

Depression

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Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion o

Brain serotonin content is dependent on plasma levels of the essential amino acid tryptophan. We investigated the behavioral effects of rapid tryptophan depletion in patients in antidepressant-induced remission.

Twenty-one patients who were depressed by DSM-III-R criteria received a 24-hour, 160-mg/d, low-tryptophan diet followed the next morning by a 16-amino acid drink, in a double-blind, placebo-controlled (acute tryptophan depletion and control testing), crossover fashion.

Total and free tryptophan levels decreased 87% and 91%, respectively, during acute tryptophan depletion. Fourteen of the 21 remitted depressed patients receiving antidepressants experienced a depressive relapse after the tryptophan-free amino acid drink, with gradual (24 to 48 hours) return to the remitted state on return to regular food intake. Control testing produced no significant behavioral effects.

Free plasma tryptophan level was negatively correlated with depression score during acute tryptophan depletion. The therapeutic effects of some antidepressant drugs may be dependent on serotonin availability.

About the Authors

Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Heninger GR. (1990) Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry. 1990 May;47(5):411-8. West Haven Veterans Administration Medical Center, CT 06516.

Comments

Dr_Abram_Hoffer

  • Posted on 05/16/2010 05:46 pm
This new work with NAD Therapy is very exciting and I think is right on target. It is indeed an energy-metabolic-deficiency (EMD) because in the absence of this coenzyme cycle almost all the reactions in the body run down... I congratulate Theo Verwey and his colleagues for this remarkable advance in using this concept and in using a simple test, the ratio of pyruvate to lactate as a diagnostic measure, to indicate the dose, duration of treatment etc.

NAD_Blood_Tests

  • Posted on 05/09/2010 06:20 am
It is known that dietary tryptophan can be converted to nicotinamide nucleotides in the body. Both the level of tryptophan and the energy content of the diet have been shown to influence the efficiency of conversion. The rate at which tryptophan is converted to nicotinamide nucleotides in the body may be expected to be influenced by the activities of the enzymes concerned with the tryptophan-NAD pathway.

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