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The life of poet and novelist Sylvia Plath -- one of the most celebrated literary figures of her generation -- is brought to the screen in this controversial screen adaptation. Born in Boston, MA, in 1932, Plath (played by Gwyneth Paltrow) developed a precocious talent as a writer and published her first poem when she was only eight years old. That same year, tragedy introduced itself into her life as Plath was forced to confront the unexpected death of her father. In 1950, she began studying at Smith College on a literary scholarship, and while she was an outstanding student, she also began suffering from bouts of extreme depression; following her junior year, she attempted suicide for the first time.
RATIONALE: Recently, a number of studies have challenged the finding that acute tryptophan depletion (TD) increases depressive symptoms in medicated, formerly depressed patients. The present study exa… Read more
Brain serotonin content is dependent on plasma levels of the essential amino acid tryptophan. We investigated the behavioral effects of rapid tryptophan depletion in patients in antidepressant-induced… Read more
BACKGROUND: Major depression is a common disorder but the pathophysiology is poorly understood. Current hypotheses implicate deficient function of brain serotonin pathways because drugs that selective… Read more
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My NAD Articles Doccumenting NAD Relevancy
Tryptophan depletion in SSRI-recovered depressed o…
Serotonin function and the mechanism of antidepres…
Relapse of depression after rapid depletion of try…