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David Basner (Tom Hanks) works in an ad agency, where he enjoys bantering with his co-workers and meets a lot of women. He hasn't been especially close to his father (Jackie Gleason) and never thought about him much until his Dad is left devastated when his wife of 36 years walks out on him. He is soon faced with serious health problems as well. Jackie Gleason portrays the father, a man who's estranged from his family while grappling with his diabetes
Diabetic retinopathy is thought to result from chronic changes in the metabolic pathways of the retina. Hyperglycemia leads to increased intracellular glucose concentrations, alterations in glucose de… Read more
AIMS/HYPOTHESIS: Studies of the role of sorbitol dehydrogenase in nerve functional deficits induced by diabetes reported contradictory results. We evaluated whether sorbitol dehydrogenase inhibition r… Read more
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My NAD Articles Doccumenting NAD Relevancy
Changes in the redox state in the retina and brain…
Evaluation of a sorbitol dehydrogenase inhibitor o…
Elevated glucose levels increase retinal glycolysi…
METHODS. Freshly isolated retinas from normal male Sprague-Dawley rats were i… Read more