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Since the discovery of NAD-dependent deacetylase activity of the silent information regulator-2 (SIR2) family ('sirtuins'), many exciting connections between protein deacetylation and energy metabolis… Read more
Neuronal cells usually utilize glucose as a principal metabolic fuel and monocarboxylates including lactate and pyruvate are alternative energetic substrates in the central nervous system.
Both aging and sleep deprivation disturb the functions of the frontal lobes. Deficits in brain energy metabolism have been reported in these conditions.
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My NAD Articles Doccumenting NAD Relevancy
Ten years of NAD-dependent SIR2 family deacetylase…
Synaptic utilization of lactate/pyruvate and neura…
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Stimulus-induced brain lactate: effects of aging a…
Neurons use not only glucose but … Read more