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BACKGROUND: This paper presents a further analysis of biochemical data collected during a 1 year prospective study of 106 cases of heat exhaustion at a deep underground metalliferous mine.

RESULTS: Multiple regression analysis results indicate that the haemoglobin, serum creatinine and plasma lactate concentrations are statistically significant predictors of the anion gap. Together, …

Hyperthermia has been shown in vitro and in vivo to potentiate the effects of ionizing irradiation. Previous studies found that hyperthermia alters the metabolism of adenosine diphosphate (ADP)-ribose polymers required for recovery from DNA damage and that poly(ADP-ribose) polymerase activity is very sensitive to cellular nicotinamide-adenine dinucleotide (NAD) levels.

Thus, the effe…

Exertional heat stroke (EHS) is an acute life-threatening emergency that necessitates the immediate institution of cooling measures. Reported here is a case of EHS in a nonacclimatized young woman who was undergoing strenuous exercise.

The patient developed many of the characteristic features of EHS, including central nervous system disturbances, lactic acidosis, rhabdomyolysis, coag…

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