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At the time of its release, Jonathan Demme's Philadelphia was the first big-budget Hollywood film to tackle the medical, political, and social issues of AIDS. Tom Hanks, in his first Academy Award-winning performance, plays Andrew Beckett, a talented lawyer at a stodgy Philadelphia law firm. The homosexual Andrew has contracted AIDS but fears informing his firm about the disease.
We report that HIV-1 infection of human cells in vitro leads to significant decreases in the intracellular concentration of NAD. This decrease varies with viral load and HIV strain.
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HIV infection decreases intracellular nicotinamide…
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