Impaired brain energy metabolism with increased regional brain lactate may play a role in the pathogenesis of Huntington's disease (HD). Magnetic resonance spectroscopy (MRS) has provided conflicting evidence, however, regarding metabolic changes.
Our objective was to evaluate the potential contribution of CSF lactate to the changes observed with MRS in HD. We performed single voxel …
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Is brain lactate increased in Huntington's disease?
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Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.
We investigated whether the Huntington\'s disease (HD) gene mutation may produce either primary or secondary effects on energy metabolism. 31P magnetic resonance spectroscopy demonstrated a significant decrease in the phosphocreatine to inorganic phosphate ratio in resting muscle of 8 patients as compared with 8 control subjects.
The cerebrospinal fluid lactate-pyruvate ratio was sig… |
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