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The activity of NAD-dependent prostaglandin 15-hydroxydehydrogenase in the corpora cavernosa of the human penis

Prostaglandins may be involved in human penile erection and erectile failure. To evaluate the possible role of prostaglandin metabolism in the penile tissue, the activity of nicotinamide adenine dinucleotide-dependent prostaglandin 15-hydroxydehydrogenase was assayed in the corpora cavernosa of the human penis.

Km values (mean +/- SD) of the enzyme for PGE1, PGE2 and PGF2 alpha were 60.1 +/- 4.2, 17.7 +/- 1.5 and 16.1 +/- 1.2 microM respectively; Vmax values (mean +/- SD) were 0.219 +/- 0.062, 0.510 +/- 0.012 and 0.424 +/- 0.007 nmol/min/mg protein respectively. The implications of these findings in the erectile process are discussed.

About the Authors

Roy AC, Adaikan PG, Sen DK, Ratnam SS. (1989) Prostaglandin 15-hydroxydehydrogenase activity in human penile corpora cavernosa and its significance in prostaglandin-mediated penile erection . Br J Urol. 1989 Aug;64(2):180-2. Department of Obstetrics and Gynaecology, NationalUniversity of Singapore, National University Hospital.

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NAD_Blood_Tests

  • Posted on 04/29/2010 04:19 am
The ratio of lactate to pyruvate reflects the NAD/NADH ratio and is useful in distinguishing primary defects. Measured enzymatically in blood or CSF as an index of defects of glucose oxidation (fed state) or gluconeogenesis (fasted). (Center Inherited Disorders Energy Metabolism at CWR University School of Medicine, Cleveland, Ohio).

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